Natural Herb Proven to Slow and Reverse Aging Hits the Market

TA-65 could be the fountain of youth.

Believers in the powers of herbal medicine will be glad to learn that the supplement TA-65 comes from the ancient Chinese herb Astragalus. But hold on before you run out and get some Astragalus at Wal-Mart. TA-65 is ultra-concentrated and requires massive amounts of the raw herb to produce a single capsule.

I have written about supplements and anti-aging for a long time, and while I am normally skeptical of claims until I delve deeply into a supplement, I have to admit that TA-65 looks like it might be the real deal. For certain TA-65 is heading in the right direction, and wild-sounding claims aside I have to admit that from what I’ve learned about the product I would be taking it right now if not for the cost. TA-65 is definitely not cheap..

Science cracks the code to reversing aging.

Understanding the nuances of human telomeres seems likely to hold keys to age-reversal. Telomeres are protective bits of DNA at the ends of our chromosomes inside our cells.

Telomeres were identified in the early 1900s, but only in the past two decades have we begun to understand them and how manipulating them might lead to a longer and healthier life. How much longer? That remains to be proven, but it looks more promising than anything I’ve ever seen.

Telomere research has shown that senior citizens who look and feel much better than average tend to have longer-than-average telomeres. It has also been shown that telomeres get shorter as we get older, and so keeping them from getting shorter seemed like it might prolong life. But it needed to be tied together and tested.

A breakthrough came when the 2009 Nobel Prize in Medicine and Physiology was awarded to Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak (all from the U.S.) for their discovery that telomeres protect DNA from being damaged during cell division.

Telomeres in plain English.

At the end of a chromosome’s DNA strand is a telomere whose job is to protect DNA during cell division. Doctor Mark Stibich at the University of California, San Diego School of Medicine explains the process as follows:

“Each time a cell divides, the DNA unwraps and the information in the DNA is copied. The process does not copy all of the DNA information – the telomeres are not copied. When the cell finishes dividing, the DNA comes back together. The telomeres lose a little bit of length each time this happens.”

Keep in mind that longer telomeres are found in humans that age better than average, and apply it to the 1961 discovery showing that after a cell divides approximately 50 times the telomeres have become shorter to the point that the DNA is susceptible to damage. Interestingly, a cell that has shortened telomeres will stop dividing. That is known as the Hayflick Limit after the scientist who made the discovery.

The Hayflick Limit enables telomere length to be used to calculate a cell’s age and how many more times it can divide before it shuts down. When a cell shuts down and stops dividing it is said to have entered senescence or old age. Got that? Old age occurs when telomeres get shorter and the cells stop dividing. For more details please visit these sites:-

All of the above helped develop the theory that keeping telomeres long and cells dividing could be the key to living longer and maybe even turning back the aging clock. But there was piece missing from the puzzle.

Enter telomerase

Keep in mind that nearly all cells are programmed to divide, and so division and the ensuing cell replication is a necessary and normal process. And so is programmed death of cells, known as apoptosis. That’s how the body balances new and old cells. Too many cells of one type can make them prone to becoming cancer.

The enzyme telomerase (telomere with ASE added to the spelling) is naturally occurring and helps sustain the all-important telomeres at the ends of our chromosomes. At the same time it controls cancer cells.

The glitch is that researchers believe that cancer cells cause release of the telomerase enzyme, which can prevent cancer cell telomeres from getting shorter (during division) and dying, which is what we want cancer cells to do.

While most cells have the genetic code to produce telomerase enzyme, a select group don’t because they need to live longer and divide more than the usual 50 times. White blood cells and sperm cells for instance. That may be interesting but the real take home message is that the enzyme has a vital role in how long cells live.

Based on the information thus far, you can conclude that keeping healthy cells alive longer could keep us alive longer. And manipulating telomeres and telomerase looks like one way it might be accomplished.

Researchers prove age-reversal is possible.

In November 2010 Harvard researchers at Dana-Farber Cancer Institute partially reversed age-related degeneration in mice. While this project achieved age-reversal under lab conditions with purpose-bred animals, it was a milestone and there is often a tipping point in science and one discovery yields more discoveries.

Between Leonard Hayflick’s early discovery and the 2010 Harvard mouse research, California biotech company, Geron, discovered and licensed TA-65 to the company known as , which has been involved in human trials since 2005.

Rejuvenation Research journal (Sept 2010) published a peer-reviewed paper concluding that, “TA-65 transiently activates telomerase, lengthens short telomeres, and rescues and restores the aging immune system in humans.” That’s science speak, but look at it again and you will see that it is talking about reversing aging processes. And the operative word is humans. There is much more info on the TA Sciences website including reports from human users of the product.

While I’ve been around long enough to be skeptical about claims made by sellers of supplements, TA-65 looks like it might be the real deal and the start of something big. It is rare when something appears able to undo effects of aging. Any product that genuinely can turn back the biological clock is going to be a smash hit no matter how much it costs.

End notes.

Best as I can tell the only downside is the cost of TA-65. Depending on the protocol one follows you can expect to pay between $200 to $1,000 per month. That will probably come down as more (or fewer) users take the product. If and when TA-65 proves to be for real there will be a mad rush for the product, and that will spawn clones and knockoffs (and also ripoffs so be careful).



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